TB-500
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TB-500 | Peptide Complex
Regenerative
TB-500 is a synthetic peptide derived from the conserved actin-binding domain of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein found in virtually all human and animal cells. Thymosin Beta-4 plays a crucial role in actin polymerization, cell migration, angiogenesis, and tissue repair. TB-500 retains the core regenerative activity of its parent molecule while offering improved stability and systemic bioavailability. It is one of the most widely studied peptides in athletic recovery, tissue repair, and regenerative medicine research.
Tissue Repair & Regeneration — TB-500 promotes the repair of damaged muscle, tendon, ligament, skin, and cardiac tissue by accelerating cell migration, differentiation, and extracellular matrix remodeling at injury sites.
Angiogenesis — Research demonstrates TB-500 stimulates new blood vessel formation (angiogenesis) in ischemic and injured tissue, improving nutrient and oxygen delivery to healing areas.
Actin Regulation & Cell Mobility — As an actin-sequestering peptide, TB-500 modulates actin dynamics within cells, directly supporting the migration of endothelial cells, keratinocytes, and progenitor cells toward injury sites.
Anti-Inflammatory Activity — Studies indicate TB-500 reduces inflammatory cytokine production and modulates immune cell infiltration at injury sites, supporting a more controlled and efficient healing environment.
Cardiac & Neural Repair Research — Preclinical studies have explored TB-500 in models of cardiac infarction and neurological injury, with results suggesting potential for cardiomyocyte survival and axonal repair in research models.
